Sclerema \Scle*re"ma\, n. [NL., fr. Gr. sklhro`s hard.] (Med.) Induration of the cellular tissue. {Sclerema of adults}. See {Scleroderma}. {Sclerema neonatorum}[NL., of the newborn], an affection characterized by a peculiar hardening and rigidity of the cutaneous and subcutaneous tissues in the newly born. It is usually fatal. Called also {skinbound disease}.